PreciDIAB

Publication in collaboration with the Montpellier teams in the scientific journal Diabetes Journal

In the publication published in the journal Diabetes in January 2020, the teams from Montpellier, led by Dr Carine Chavey, and that from Lille, led by Dr Jean-Sébastien Annicotte, demonstrated the important role played by the Lamin C protein in glucose intolerance linked to aging, diabetes and obesity.

The lamins, A, C and progerin, obtained by splicing the Lmna gene, are proteins that structure chromatin and help maintain cellular functions during aging. Mutations in the LMNA gene lead to the development of laminopathies, one of the (best known) main ones is progeria. These lamins have also been shown to play a key role in the control of glucose and lipid metabolism, having consequences for the development of metabolic diseases such as obesity and diabetes.
 
In this study, the Montpellier and Lille teams showed that maintaining the expression of Lamine C protects against the development of diabetes by allowing the cells that produce insulin, the pancreatic β cells, to adapt and regenerate. These data open up new avenues of research in the regeneration and cell therapy of diabetes by proposing the Lmna gene as a potential target for the treatment of diabetes.