{"id":15836,"date":"2022-08-01T19:41:59","date_gmt":"2022-08-01T17:41:59","guid":{"rendered":"https:\/\/precidiab.tw-es1.ovh\/research-health\/projets-de-recherche\/"},"modified":"2022-08-19T10:17:58","modified_gmt":"2022-08-19T08:17:58","slug":"research-projects","status":"publish","type":"page","link":"https:\/\/www.precidiab.org\/en\/research-health\/research-projects\/","title":{"rendered":"Research Projects"},"content":{"rendered":"\t\t<div data-elementor-type=\"wp-page\" data-elementor-id=\"15836\" class=\"elementor elementor-15836 elementor-39\" data-elementor-post-type=\"page\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-211fdf4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"211fdf4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-4ae2861\" data-id=\"4ae2861\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-edde7bf elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"edde7bf\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-04c243a\" data-id=\"04c243a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-306258c elementor-toc--content-ellipsis elementor-toc--minimized-on-tablet elementor-widget elementor-widget-table-of-contents\" data-id=\"306258c\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;headings_by_tags&quot;:[&quot;h2&quot;],&quot;container&quot;:&quot;.sommaire&quot;,&quot;exclude_headings_by_selector&quot;:[],&quot;marker_view&quot;:&quot;bullets&quot;,&quot;collapse_subitems&quot;:&quot;yes&quot;,&quot;icon&quot;:{&quot;value&quot;:&quot;fas fa-circle&quot;,&quot;library&quot;:&quot;fa-solid&quot;},&quot;no_headings_message&quot;:&quot;No headings were found on this page.&quot;,&quot;minimize_box&quot;:&quot;yes&quot;,&quot;minimized_on&quot;:&quot;tablet&quot;,&quot;hierarchical_view&quot;:&quot;yes&quot;,&quot;min_height&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;min_height_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"table-of-contents.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-toc__header\">\n\t\t\t\t\t\t<h2 class=\"elementor-toc__header-title\">\n\t\t\t\tSUMMARY - Research Projects\t\t\t<\/h2>\n\t\t\t\t\t\t\t\t\t\t<div class=\"elementor-toc__toggle-button elementor-toc__toggle-button--expand\" role=\"button\" tabindex=\"0\" aria-controls=\"elementor-toc__306258c\" aria-expanded=\"true\" aria-label=\"Open table of contents\"><i aria-hidden=\"true\" class=\"fas fa-chevron-down\"><\/i><\/div>\n\t\t\t\t<div class=\"elementor-toc__toggle-button elementor-toc__toggle-button--collapse\" role=\"button\" tabindex=\"0\" aria-controls=\"elementor-toc__306258c\" aria-expanded=\"true\" aria-label=\"Close table of contents\"><i aria-hidden=\"true\" class=\"fas fa-chevron-up\"><\/i><\/div>\n\t\t\t\t\t<\/div>\n\t\t\t\t<div id=\"elementor-toc__306258c\" class=\"elementor-toc__body elementor-toc__list-items--collapsible\">\n\t\t\t<div class=\"elementor-toc__spinner-container\">\n\t\t\t\t<i class=\"elementor-toc__spinner eicon-animation-spin eicon-loading\" aria-hidden=\"true\"><\/i>\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-9b32d2b\" data-id=\"9b32d2b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4b80f57 elementor-widget elementor-widget-image\" data-id=\"4b80f57\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" decoding=\"async\" width=\"512\" height=\"512\" src=\"https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/adn-1.png\" class=\"attachment-large size-large wp-image-14725\" alt=\"\" srcset=\"https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/adn-1.png 512w, https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/adn-1-300x300.png 300w, https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/adn-1-150x150.png 150w\" sizes=\"(max-width: 512px) 100vw, 512px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<div class=\"elementor-element elementor-element-bab3207 elementor-grid-1 elementor-posts--thumbnail-top elementor-grid-tablet-2 elementor-grid-mobile-1 elementor-widget elementor-widget-posts\" data-id=\"bab3207\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;custom_columns&quot;:&quot;1&quot;,&quot;custom_columns_tablet&quot;:&quot;2&quot;,&quot;custom_columns_mobile&quot;:&quot;1&quot;,&quot;custom_row_gap&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:35,&quot;sizes&quot;:[]},&quot;custom_row_gap_tablet&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]},&quot;custom_row_gap_mobile&quot;:{&quot;unit&quot;:&quot;px&quot;,&quot;size&quot;:&quot;&quot;,&quot;sizes&quot;:[]}}\" data-widget_type=\"posts.custom\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t      <div class=\"ecs-posts elementor-posts-container elementor-posts   elementor-grid elementor-posts--skin-custom\" data-settings=\"{&quot;current_page&quot;:1,&quot;max_num_pages&quot;:0,&quot;load_method&quot;:&quot;&quot;,&quot;widget_id&quot;:&quot;bab3207&quot;,&quot;post_id&quot;:15836,&quot;theme_id&quot;:15836,&quot;change_url&quot;:false,&quot;reinit_js&quot;:false}\">\n      \t\t<article id=\"post-15842\" class=\"elementor-post elementor-grid-item ecs-post-loop post-15842 projet type-projet status-publish hentry\">\n\t\t\t\t<div data-elementor-type=\"loop\" data-elementor-id=\"16070\" class=\"elementor elementor-16070 elementor-14850 elementor-14850 post-15842 projet type-projet status-publish hentry ast-article-single\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e6caa03 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e6caa03\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c97a22f\" data-id=\"c97a22f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-719d76d sommaire elementor-widget elementor-widget-theme-post-title elementor-page-title elementor-widget-heading\" data-id=\"719d76d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-title.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">Subclinical markers of diabetes and obesity<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4fa5665 elementor-widget elementor-widget-theme-post-content\" data-id=\"4fa5665\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"15842\" class=\"elementor elementor-15842 elementor-14746 elementor-14746 elementor-14746\" data-elementor-post-type=\"projet\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-a20ccf6 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"a20ccf6\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-6ca316c\" data-id=\"6ca316c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-67f4bd5 elementor-widget elementor-widget-heading\" data-id=\"67f4bd5\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-medium\">Diabetes is a chronic disease most often linked to a family history including obesity and gestational diabetes. Understanding obesity requires the discovery of molecular markers of pre-diabetes specific to each situation, from an early age. The validation of these markers should allow the implementation of targeted preventive interventions in people with a clearly identified risk profile.<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-e7743fd elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e7743fd\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wider\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-4b4d6b9\" data-id=\"4b4d6b9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4e6507c elementor-widget elementor-widget-image\" data-id=\"4e6507c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" fetchpriority=\"high\" decoding=\"async\" width=\"625\" height=\"833\" src=\"https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Dr.-Amelie-Bonnefond-portrait-15.jpg\" class=\"attachment-large size-large wp-image-14742\" alt=\"\" srcset=\"https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Dr.-Amelie-Bonnefond-portrait-15.jpg 625w, https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Dr.-Amelie-Bonnefond-portrait-15-225x300.jpg 225w, https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Dr.-Amelie-Bonnefond-portrait-15-300x400.jpg 300w\" sizes=\"(max-width: 625px) 100vw, 625px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-f27b17e elementor-absolute elementor-widget elementor-widget-heading\" data-id=\"f27b17e\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-small\">Person in charge: Dr. Am\u00e9lie Bonnefond<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-a54f563\" data-id=\"a54f563\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-677c3a6 elementor-widget elementor-widget-heading\" data-id=\"677c3a6\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">Prediction of the incidence of T2DM in families from the DESCENDENCE cohort<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-text-editor elementor-element elementor-element-921296a elementor-widget elementor-widget-text-editor\" data-id=\"921296a\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>The heritability of type 2 diabetes (T2DM) is estimated to be between 40 and 75%. To effectively prevent this disease, it is necessary to\u00a0<strong>identify as early as possible<\/strong>\u00a0future diabetic patients who are, in most cases, descendants of diabetic patients.<\/p><p>The objective is to\u00a0<strong>genetically and metabolically characterize these families<\/strong>\u00a0to identify risk profiles of subclinical development of a future T2DM so as to put in place more effective preventive strategies. From the data and samples from the DESCENDANCE cohort, we wish to combine genetic, metabolomic and phenotypic biomarkers, we intend to establish an equation allowing better prevention of T2DM.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-3bfb8d7 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"3bfb8d7\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wider\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-e233f2a\" data-id=\"e233f2a\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8d0c6ca elementor-widget elementor-widget-image\" data-id=\"8d0c6ca\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"625\" height=\"833\" src=\"https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Prof.-Philippe-Froguel-portrait-14.jpg\" class=\"attachment-large size-large wp-image-14739\" alt=\"\" srcset=\"https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Prof.-Philippe-Froguel-portrait-14.jpg 625w, https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Prof.-Philippe-Froguel-portrait-14-225x300.jpg 225w, https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Prof.-Philippe-Froguel-portrait-14-300x400.jpg 300w\" sizes=\"(max-width: 625px) 100vw, 625px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-eb60a50 elementor-absolute elementor-widget elementor-widget-heading\" data-id=\"eb60a50\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-small\">Person in charge:  Prof. Philippe Froguel<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-5b75367\" data-id=\"5b75367\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-85c0f66 elementor-widget elementor-widget-heading\" data-id=\"85c0f66\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">Understanding the fetal epigenic risk in T2DM\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-text-editor elementor-element elementor-element-a382daf elementor-widget elementor-widget-text-editor\" data-id=\"a382daf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Prematurity affects 6% of newborns<\/strong>, with adverse consequences on the subsequent development of these children, in particular an increased risk of T2DM in adulthood. Knowing the nature of the biological biomarkers associated with prematurity would help prevent its early and distant consequences.<\/p><p>This project proposes to\u00a0<strong>identify the epigenetic factors caused by prematurity<\/strong>\u00a0through the study of the cord blood of premature children, to better understand the mechanisms of accelerated aging in these subjects and to\u00a0<strong>set in motion effective preventive strategies<\/strong>\u00a0for these chronic diseases. age-related.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a0f110c elementor-widget elementor-widget-heading\" data-id=\"a0f110c\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">Prediction of the incidence of obesity and prediabetes<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-text-editor elementor-element elementor-element-acc1d64 elementor-widget elementor-widget-text-editor\" data-id=\"acc1d64\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Obesity in children and adolescents, if not managed, is the main risk factor for the development of chronic obesity in adults and then type 2 diabetes. is therefore important for reducing the incidence of new cases of diabetes and more generally of metabolic diseases.<br \/>Our goal is to identify from childhood,\u00a0<strong>thanks to genetics and microbiome analysis<\/strong>, people with a high risk profile so as to put in place monitoring and prevention measures and if necessary to implement a personalized support.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-508da3a elementor-section-full_width elementor-section-stretched elementor-section-height-default elementor-section-height-default\" data-id=\"508da3a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5cee77c\" data-id=\"5cee77c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6870e12 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6870e12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article id=\"post-15843\" class=\"elementor-post elementor-grid-item ecs-post-loop post-15843 projet type-projet status-publish has-post-thumbnail hentry\">\n\t\t\t\t<div data-elementor-type=\"loop\" data-elementor-id=\"16070\" class=\"elementor elementor-16070 elementor-14850 elementor-14850 post-15843 projet type-projet status-publish has-post-thumbnail hentry ast-article-single\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e6caa03 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e6caa03\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c97a22f\" data-id=\"c97a22f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-719d76d sommaire elementor-widget elementor-widget-theme-post-title elementor-page-title elementor-widget-heading\" data-id=\"719d76d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-title.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">Risk markers for complications<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4fa5665 elementor-widget elementor-widget-theme-post-content\" data-id=\"4fa5665\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"15843\" class=\"elementor elementor-15843 elementor-14743 elementor-14743 elementor-14743\" data-elementor-post-type=\"projet\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-285e2ed elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"285e2ed\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-07cb94d\" data-id=\"07cb94d\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-c7b3c1d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"c7b3c1d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wider\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-a19a8cc\" data-id=\"a19a8cc\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-bee3f1b elementor-widget elementor-widget-image\" data-id=\"bee3f1b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"625\" height=\"833\" src=\"https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Prof.-Inga-Prokopenko-portrait-13.jpg\" class=\"attachment-large size-large wp-image-14745\" alt=\"\" srcset=\"https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Prof.-Inga-Prokopenko-portrait-13.jpg 625w, https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Prof.-Inga-Prokopenko-portrait-13-225x300.jpg 225w, https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Prof.-Inga-Prokopenko-portrait-13-300x400.jpg 300w\" sizes=\"(max-width: 625px) 100vw, 625px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-75b102d elementor-absolute elementor-widget elementor-widget-heading\" data-id=\"75b102d\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-small\">Person in charge : Prof. Inga Prokopenko<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-5f423d2\" data-id=\"5f423d2\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-4d557c1 elementor-widget elementor-widget-heading\" data-id=\"4d557c1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">Study of the links between diabetes and cancer risks\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-text-editor elementor-element elementor-element-2964520 elementor-widget elementor-widget-text-editor\" data-id=\"2964520\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>Diabetic complications are very difficult to predict and lead to an increase in early mortality<\/strong>. At present, there is no relevant marker for the risk of complications, especially for patients in stressful life situations (eg: unstabilized insulin-dependent patient).<\/p><p>Our goal is to\u00a0<strong>make new discoveries in the assessment of the risk of complications and comorbidities associated with diabetes<\/strong>\u00a0in order to allow more effective management of patients in potentially critical situations, particularly in cases of association between diabetes and cancer.<\/p><p>Indeed, the prevalence of breast and colorectal cancers is higher in people with diabetes and also leads to higher mortality. It is therefore essential to\u00a0<strong>develop tools to assess the risk of cancer in diabetic patients at an early stage<\/strong>, notably through the use of genetics, epigenetics and microbiome analysis in patients with T2D.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-508da3a elementor-section-full_width elementor-section-stretched elementor-section-height-default elementor-section-height-default\" data-id=\"508da3a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5cee77c\" data-id=\"5cee77c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6870e12 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6870e12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article id=\"post-15844\" class=\"elementor-post elementor-grid-item ecs-post-loop post-15844 projet type-projet status-publish has-post-thumbnail hentry\">\n\t\t\t\t<div data-elementor-type=\"loop\" data-elementor-id=\"16070\" class=\"elementor elementor-16070 elementor-14850 elementor-14850 post-15844 projet type-projet status-publish has-post-thumbnail hentry ast-article-single\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e6caa03 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e6caa03\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c97a22f\" data-id=\"c97a22f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-719d76d sommaire elementor-widget elementor-widget-theme-post-title elementor-page-title elementor-widget-heading\" data-id=\"719d76d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-title.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">Genomic medicine for diabetes and obesity<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4fa5665 elementor-widget elementor-widget-theme-post-content\" data-id=\"4fa5665\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"15844\" class=\"elementor elementor-15844 elementor-14740 elementor-14740 elementor-14740\" data-elementor-post-type=\"projet\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-442b75d elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"442b75d\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-cbf8c6e\" data-id=\"cbf8c6e\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-a791742 elementor-widget elementor-widget-heading\" data-id=\"a791742\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-medium\">10% of early diabetes are atypical (not classified DT1 or DT2). However, 80% of these diabetes have a monogenic origin for which effective personalized treatments are possible. These monogenic forms are also present in 5% of T2DMs and 5% of childhood obesity.\nThe development of Next Generation Sequencing (NGS) methods reveals the possibility of a targeted molecular diagnosis allowing personalized genomic medicine.<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-574dadb elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"574dadb\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wider\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-0587893\" data-id=\"0587893\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-68d7307 elementor-widget elementor-widget-image\" data-id=\"68d7307\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img fetchpriority=\"high\" fetchpriority=\"high\" decoding=\"async\" width=\"625\" height=\"833\" src=\"https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Dr.-Amelie-Bonnefond-portrait-15.jpg\" class=\"attachment-large size-large wp-image-14742\" alt=\"\" srcset=\"https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Dr.-Amelie-Bonnefond-portrait-15.jpg 625w, https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Dr.-Amelie-Bonnefond-portrait-15-225x300.jpg 225w, https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Dr.-Amelie-Bonnefond-portrait-15-300x400.jpg 300w\" sizes=\"(max-width: 625px) 100vw, 625px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-ca05c54 elementor-absolute elementor-widget elementor-widget-heading\" data-id=\"ca05c54\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-small\">Person in charge: Dr. Am\u00e9lie Bonnefond<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-7a2db3b\" data-id=\"7a2db3b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-7ee3571 elementor-widget elementor-widget-heading\" data-id=\"7ee3571\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">Genomic medicine for diabetes<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-text-editor elementor-element elementor-element-fddb389 elementor-widget elementor-widget-text-editor\" data-id=\"fddb389\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>T2D is indeed considered a complex genetic disease<\/strong>\u00a0: most T2D is considered to be \u201cpolygenic forms\u201d which depend on multiple common genetic variants acting in combination with environmental risk factors. However, there are also rarer and generally more severe forms known as \u201cmonogenic forms\u201d, in which<strong>\u00a0a single constitutional genetic mutation is sufficient to cause diabetes<\/strong>\u00a0most often at an early age. Genetic investigations of these monogenic forms have revealed crucial players involved in the development and function of pancreatic \u03b2 cells, leading to the discovery of real \u201ccase studies\u201d of personalized genomic medicine.<\/p><p>In this project, we wish to<strong>\u00a0sequence the genes involved in monogenic forms of diabetes and associated diseases in patients with T2D<\/strong>\u00a0in order to launch an interventional study on the adaptation of treatment and \/ or the specific clinical investigation of organs. The aim is to\u00a0<strong>assess the effectiveness of these interventions for patients and the gains in terms of public health<\/strong>.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-07da0ef elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"07da0ef\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wider\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-0c56c1b\" data-id=\"0c56c1b\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-e40933d elementor-widget elementor-widget-image\" data-id=\"e40933d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img decoding=\"async\" width=\"625\" height=\"833\" src=\"https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Prof.-Philippe-Froguel-portrait-14.jpg\" class=\"attachment-large size-large wp-image-14739\" alt=\"\" srcset=\"https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Prof.-Philippe-Froguel-portrait-14.jpg 625w, https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Prof.-Philippe-Froguel-portrait-14-225x300.jpg 225w, https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Prof.-Philippe-Froguel-portrait-14-300x400.jpg 300w\" sizes=\"(max-width: 625px) 100vw, 625px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-a62e3c9 elementor-absolute elementor-widget elementor-widget-heading\" data-id=\"a62e3c9\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-small\">Responsable : Prof. Philippe Froguel<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-538a342\" data-id=\"538a342\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-f8834a1 elementor-widget elementor-widget-heading\" data-id=\"f8834a1\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">Genomic medicine for obesity<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-text-editor elementor-element elementor-element-a396c01 elementor-widget elementor-widget-text-editor\" data-id=\"a396c01\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p><strong>In some countries, up to 25% of children are obese<\/strong>, suggesting a reduction in their life expectancy of 5 to 10 years. Childhood obesity is the dominant risk factor for persistent adult obesity and is associated with delayed schooling and harmful social isolation. Often overlooked, obesity puts many patients at a diagnostic and therapeutic level.<\/p><p><strong>Common obesity is a multifactorial disease<\/strong>. However, there is a monogenic component of obesity (phenotypically isolated or syndromic) with disruption of the hypothalamic appetite control circuits. We estimate that\u00a0<strong>in France at least 10,000 children have a monogenic form of obesity<\/strong>, most of them neither being diagnosed nor cared for properly. We were pioneers and world leaders in identifying the various obesity genes. Recently, a medicament (setmelanotide \u2013 MC4R agonist)\u00a0<strong>has been shown to reduce hunger for a long time and allow significant weight reduction in carriers of pathogenic mutations in the melanocortin pathway<\/strong>.<\/p><p>Here we will analyze the genome of children and adults with suspected monogenic obesity undiagnosed to date, and through this project we intend to unlock the diagnostic locks of severe monogenic obesity paving the way for efficient precision medicine.<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-508da3a elementor-section-full_width elementor-section-stretched elementor-section-height-default elementor-section-height-default\" data-id=\"508da3a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5cee77c\" data-id=\"5cee77c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6870e12 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6870e12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<article id=\"post-15845\" class=\"elementor-post elementor-grid-item ecs-post-loop post-15845 projet type-projet status-publish hentry\">\n\t\t\t\t<div data-elementor-type=\"loop\" data-elementor-id=\"16070\" class=\"elementor elementor-16070 elementor-14850 elementor-14850 post-15845 projet type-projet status-publish hentry ast-article-single\" data-elementor-post-type=\"elementor_library\">\n\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-e6caa03 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"e6caa03\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-c97a22f\" data-id=\"c97a22f\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-719d76d sommaire elementor-widget elementor-widget-theme-post-title elementor-page-title elementor-widget-heading\" data-id=\"719d76d\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-title.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-large\">Nutrition, environment and metabolic diseases<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-4fa5665 elementor-widget elementor-widget-theme-post-content\" data-id=\"4fa5665\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"theme-post-content.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div data-elementor-type=\"wp-post\" data-elementor-id=\"15845\" class=\"elementor elementor-15845 elementor-14734 elementor-14734 elementor-14734\" data-elementor-post-type=\"projet\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-6256fbc elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"6256fbc\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-172b9c9\" data-id=\"172b9c9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<section class=\"elementor-section elementor-inner-section elementor-element elementor-element-dbd73a4 elementor-section-boxed elementor-section-height-default elementor-section-height-default\" data-id=\"dbd73a4\" data-element_type=\"section\" data-e-type=\"section\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-wider\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-4db6ff9\" data-id=\"4db6ff9\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-8d00ebf elementor-widget elementor-widget-image\" data-id=\"8d00ebf\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"image.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<img loading=\"lazy\" loading=\"lazy\" decoding=\"async\" width=\"625\" height=\"833\" src=\"https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Marc-Emmanuel-Dumas-portrait-PreciDIAB-17-12.png\" class=\"attachment-large size-large wp-image-14736\" alt=\"\" srcset=\"https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Marc-Emmanuel-Dumas-portrait-PreciDIAB-17-12.png 625w, https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Marc-Emmanuel-Dumas-portrait-PreciDIAB-17-12-225x300.png 225w, https:\/\/www.precidiab.org\/wp-content\/uploads\/2022\/08\/Marc-Emmanuel-Dumas-portrait-PreciDIAB-17-12-300x400.png 300w\" sizes=\"auto, (max-width: 625px) 100vw, 625px\" \/>\t\t\t\t\t\t\t\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-409ae19 elementor-absolute elementor-widget elementor-widget-heading\" data-id=\"409ae19\" data-element_type=\"widget\" data-e-type=\"widget\" data-settings=\"{&quot;_position&quot;:&quot;absolute&quot;}\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<h2 class=\"elementor-heading-title elementor-size-small\">Person in charge: Dr. Marc-Emmanuel Dumas\n<\/h2>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t<div class=\"elementor-column elementor-col-50 elementor-inner-column elementor-element elementor-element-0cc2ea7\" data-id=\"0cc2ea7\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-text-editor elementor-element elementor-element-dda1a35 elementor-widget elementor-widget-text-editor\" data-id=\"dda1a35\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"text-editor.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<p>Metabolic disorders and cardiovascular complications are multifactorial diseases resulting from the strong interaction between lifestyle factors such as nutrition, drug treatments or physical activity, the microbiome and the human host genome.<\/p><p>From the metabolomic, metagenomic and epigenomic data generated by the clinical studies of PreciDIAB and the partner studies, our objective to assess the impact of nutrition, medication and lifestyle on (cardio) metabolic diseases, in particular of particular interest to the role played by the microbiome and its metabolites as mediators.<\/p><p><strong>We thus wish to provide new hypotheses on the spectrum of cardiometabolic diseases<\/strong>\u00a0that we will validate in the PreciDIAB cohorts by a holistic approach of the links between lifestyle, microbiome and cardiometabolic risk<\/p>\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-508da3a elementor-section-full_width elementor-section-stretched elementor-section-height-default elementor-section-height-default\" data-id=\"508da3a\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;}\">\n\t\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-5cee77c\" data-id=\"5cee77c\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-6870e12 elementor-widget-divider--view-line elementor-widget elementor-widget-divider\" data-id=\"6870e12\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"divider.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t<div class=\"elementor-divider\">\n\t\t\t<span class=\"elementor-divider-separator\">\n\t\t\t\t\t\t<\/span>\n\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t\t\t<\/article>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<section class=\"elementor-section elementor-top-section elementor-element elementor-element-887d4d6 elementor-section-full_width elementor-section-stretched elementor-section-height-default elementor-section-height-default\" data-id=\"887d4d6\" data-element_type=\"section\" data-e-type=\"section\" data-settings=\"{&quot;stretch_section&quot;:&quot;section-stretched&quot;,&quot;background_background&quot;:&quot;classic&quot;,&quot;shape_divider_top&quot;:&quot;opacity-tilt&quot;}\">\n\t\t\t\t\t<div class=\"elementor-shape elementor-shape-top\" aria-hidden=\"true\" data-negative=\"false\">\n\t\t\t<svg xmlns=\"http:\/\/www.w3.org\/2000\/svg\" viewBox=\"0 0 2600 131.1\" preserveAspectRatio=\"none\">\n\t<path class=\"elementor-shape-fill\" d=\"M0 0L2600 0 2600 69.1 0 0z\"\/>\n\t<path class=\"elementor-shape-fill\" style=\"opacity:0.5\" d=\"M0 0L2600 0 2600 69.1 0 69.1z\"\/>\n\t<path class=\"elementor-shape-fill\" style=\"opacity:0.25\" d=\"M2600 0L0 0 0 130.1 2600 69.1z\"\/>\n<\/svg>\t\t<\/div>\n\t\t\t\t\t<div class=\"elementor-container elementor-column-gap-default\">\n\t\t\t\t\t<div class=\"elementor-column elementor-col-100 elementor-top-column elementor-element elementor-element-d7e7626\" data-id=\"d7e7626\" data-element_type=\"column\" data-e-type=\"column\">\n\t\t\t<div class=\"elementor-widget-wrap elementor-element-populated\">\n\t\t\t\t\t\t<div class=\"elementor-element elementor-element-99fcbf8 elementor-widget elementor-widget-heading\" data-id=\"99fcbf8\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"heading.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t<p class=\"elementor-heading-title elementor-size-large\">Discover...<\/p>\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-7f7970b elementor-align-left elementor-widget__width-auto elementor-widget elementor-widget-button\" data-id=\"7f7970b\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-lg elementor-animation-grow\" href=\"https:\/\/www.precidiab.org\/en\/research-health\/translational-research\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">About translational research<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t<div class=\"elementor-element elementor-element-be9727e elementor-align-left elementor-widget__width-auto elementor-widget elementor-widget-button\" data-id=\"be9727e\" data-element_type=\"widget\" data-e-type=\"widget\" data-widget_type=\"button.default\">\n\t\t\t\t<div class=\"elementor-widget-container\">\n\t\t\t\t\t\t\t\t\t<div class=\"elementor-button-wrapper\">\n\t\t\t\t\t<a class=\"elementor-button elementor-button-link elementor-size-lg elementor-animation-grow\" href=\"https:\/\/www.precidiab.org\/en\/research-health\/platforms-and-equipment\/\">\n\t\t\t\t\t\t<span class=\"elementor-button-content-wrapper\">\n\t\t\t\t\t\t\t\t\t<span class=\"elementor-button-text\">Platforms and equipment<\/span>\n\t\t\t\t\t<\/span>\n\t\t\t\t\t<\/a>\n\t\t\t\t<\/div>\n\t\t\t\t\t\t\t\t<\/div>\n\t\t\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/div>\n\t\t\t\t\t<\/div>\n\t\t<\/section>\n\t\t\t\t<\/div>\n\t\t","protected":false},"excerpt":{"rendered":"<p>SUMMARY &#8211; Research Projects Discover&#8230; About translational research Platforms and equipment<\/p>\n","protected":false},"author":2,"featured_media":14717,"parent":15766,"menu_order":0,"comment_status":"closed","ping_status":"closed","template":"","meta":{"_acf_changed":false,"_monsterinsights_skip_tracking":false,"_monsterinsights_sitenote_active":false,"_monsterinsights_sitenote_note":"","_monsterinsights_sitenote_category":0,"site-sidebar-layout":"no-sidebar","site-content-layout":"page-builder","ast-site-content-layout":"default","site-content-style":"default","site-sidebar-style":"default","ast-global-header-display":"","ast-banner-title-visibility":"","ast-main-header-display":"","ast-hfb-above-header-display":"","ast-hfb-below-header-display":"","ast-hfb-mobile-header-display":"","site-post-title":"disabled","ast-breadcrumbs-content":"","ast-featured-img":"disabled","footer-sml-layout":"","ast-disable-related-posts":"","theme-transparent-header-meta":"default","adv-header-id-meta":"","stick-header-meta":"","header-above-stick-meta":"","header-main-stick-meta":"","header-below-stick-meta":"","astra-migrate-meta-layouts":"default","ast-page-background-enabled":"default","ast-page-background-meta":{"desktop":{"background-color":"var(--ast-global-color-4)","background-image":"","background-repeat":"repeat","background-position":"center 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