Pr. Charlotte Cordonnier

Pr. Charlotte Cordonnier

Neurologist at Lille University Hospital and researcher at Inserm.

Today, Professor Charlotte Cordonnier explains her involvement in the National PreciDIAB Center as a neurologist working on the prevention of comorbidities in diabetic patients.

Why, as a neurologist, did you choose to get involved in the Center National PreciDIAB?

I am a neurologist and I treat stroke patients. Among the patients we treat urgently, a third of them are diabetics; therefore their prognosis is more severe. However, even today, the management of diabetic patients is the same as for those who do not. However, it is probable that certain diseases, and in particular in my specialty, the cerebrovascular disease is different in these diabetic people. Customizing care based on patient characteristics is one of the key elements in improving our medical practices.

What are the projects that you are going to carry out within the National Center, and what are their objectives?

Diabetes affects the brain, nerves, heart, kidneys, eyes, and many other organs. Initially, we bring together in PreciDIAB doctors specializing in all these complications. It is rare to have such a multidisciplinary approach, and this is one of the major strengths of the National Center. Understanding what leads to complications related to diabetes will then allow us to develop strategies for the prevention and protection of these very important organs, the brain and the heart.

What are the ambitions in terms of expected results? How will these perspectives change the understanding or the way we manage metabolic diseases and diabetes in particular?

We will first create cohorts of diabetic patients. We will explore finely and in a non-invasive way, the functioning of their brains and their hearts by comparing them to non-diabetic patients. For example, the exploration of the brain will consist of an assessment of cognitive functions (visual or verbal memory, language, writing, reading, arithmetic, attention, etc.). An evaluation of the morphology of the brain will be done by a brain MRI and its functioning by a functional MRI. These observations will, in the long term, make it possible to identify the factors favoring complications of the brain (stroke or memory disorders). Thus, we can then move on to the second step, which will be to evaluate in a clinical study new prevention strategies specific to diabetic patients.

Promoting this multidisciplinary and preventive clinical approach within PreciDIAB is an exciting adventure.

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